Select Options to open an Outlook Options window.Outlook may start in Safe Mode when there are outdated add-ins that conflict with the software. Therefore, if you disable Outlook add-ins, the software may start in safe mode. Users can disable Outlook add-ins as follows. Uncheck the option Run this program in compatibility modeįix Outlook when it only starts in safe mode 1.Fix Outlook when it only starts in safe mode.Update KB3114409 (from late 2015) caused an Outlook error where email software only starts in safe mode for some users. Consequently, some users cannot open Outlook in its standard mode. The software starts without custom toolbar settings or extensions in Safe Mode, and users cannot save preferences or templates. These are some of the resolutions that can fix Outlook applications that only start in Safe Mode.